Study for the metabolic regulation and NASH pathophysiology through the insulin-mTOR signaling
Description: The pathological mechanism of metabolic disorders as well as non-alcoholic steatohepatitis (NASH) based on systemic insulin resistance remained unclear. By this study using adipocyte-specific PDK1/FoxO1 deficient mice, it was shown that dysregulation of the PDK1-FoxO1 pathway causes systemic insulin resistance through the lipid mediator LTB4. The significance of the novel adipokine TSP-1 in NASH pathology was also studied using TSP-1 deficient mice. Furthermore, downregulation of the mTOR pathway in adipocytes was shown to contribute to a part of the pathology of metabolic disorders and NASH.
Amount: ¥4,420,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2018-04-01
End date: 2021-03-31
Investigator: Tetsuya Hosooka
Institution: Kobe University
Funded outputs count: 6
Funder award ID: 18K08478
OpenAlex ID: G6972246735