The mechanisms of extracellular ion homeostasis by brain fluid dynamics
Description: The cerebral spinal fluid (CSF) flow is as well disrupted by stroke. In this study, we found that the adrenergic receptor (AdR) blockade significantly reduced the infarct area. We also found that the AdR blockade maintains the expression of the brain water channel, aquaporin 4 (AQP4), which is involved in the CSF flow. The mechanisms of the AdR blockade may be the improvement of CSF flow and facilitation of normalization of extracellular potassium ion, due to the preservation of AQP4. We believe that CSF will play an essential role in protecting a healthy brain and maintaining a normal brain environment.
Amount: ¥4,160,000
Funding type: fellowship
Funder scheme: Grant-in-Aid for Early-Career Scientists
Start date: 2018-04-01
End date: 2020-03-31
Investigator: Hiromu Monai
Institution: Ochanomizu University
Funded outputs count: 16
Funder award ID: 18K14859
OpenAlex ID: G6973501251