Roles of methionine metabolism in the regulation of lifespan in yeast
Description: Elucidation of the mechanism of aging and lifespan control is an important issue for understanding human aging and achieving extension of healthy lifespan (a period in which daily life without disability). We have succeeded in obtaining a mutant strain using Saccharomyces cerevisiae that has a significantly longer lifespan than the wild strain. Therefore, we aimed to clarify the novel mechanism of lifespan using this mutant strain. As a result, we found that the methionine metabolite is related to the lifespan extension. We also discovered that this longevity gene greatly contributed to the brewing characteristics of sake yeast, and aimed at application development using that knowledge.
Amount: ¥17,810,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (B)
Start date: 2016-04-01
End date: 2020-03-31
Investigator: Masaki Mizunuma
Institution: Hiroshima University
Funded outputs count: 2
Funder award ID: 16H04898
OpenAlex ID: G6999840408