Deciphering the role of granzyme K in immune and organismal aging
Description: This project seeks to elucidate the role of granzyme K, a serine protease markedly elevated in aged T cells, in driving immune and organismal aging. Leveraging a well-established colony of aged granzyme K knockout mice, a multidisciplinary network of collaborators, and extensive expertise in studying immune and organismal function both in vitro and in vivo, this research aims to uncover whether this 'hallmark of aging' actively contributes to the biological aging process. The anticipated outcomes include a deeper understanding of: (i) the mechanisms underlying aging, (ii) the connection between immune aging and organismal decline, and (iii) potential therapeutic avenues to reprogram or rejuvenate the biological decline that occurs with age.
Funder: Australian Research Council
Amount: A$999,300
Funding type: research
Funder scheme: Discovery Projects
Start date: 2026-01-01
End date: 2029-12-31
Investigator: Nicole Gruta
Institution: Monash University
Funded outputs count: 0
Funder award ID: DP260104042
OpenAlex ID: G702530758