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Role of adipose tissue cellular composition on healthy metabolism

Description: Narrative Identifying the mechanism and/or causes of extended longevity and delayed aging is one of the greatest scientific challenges of the 21st century. Do these mechanism involve genetics, lifestyle or dietary choices? If one could identify the mechanism involved, future research would have targets to extend lifespan and improve the “healthspan” of the human race.
Funding type: research
Funder scheme: R15
Start date: 2018-08-01
End date: 2022-07-31
Investigator: MICHAL MATEUSZ MASTERNAK
Institution: UNIVERSITY OF CENTRAL FLORIDA
Funded outputs count: 26
Funder award ID: R15AG059190
OpenAlex ID: G1365080382
Cellular senescence in skin‐related research: Targeted signaling pathways and naturally occurring therapeutic agents
2023 · Aleksandra Dańczak‐Pazdrowska, Justyna Gornowicz‐Porowska, et al. · Aging Cell · 58
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microRNA-449a reduces growth hormone-stimulated senescent cell burden through PI3K-mTOR signaling
2023 · Sarah Noureddine, Jia Nie, et al. · Proceedings of the National Academy of Sciences · 16
GH deficiency confers protective advantages against Alzheimer’s disease through rescued miRNA expression profile in APP/PS1 mice
2022 · Sarah Noureddine, Tatiana Saccon, et al. · GeroScience · 12
Senolytic treatment reverses obesity-mediated senescent cell accumulation in the ovary
2022 · Jéssica D. Hense, Driele N. Garcia, et al. · GeroScience · 36
Plasma miRNA Profile of Crohn’s Disease and Rheumatoid Arthritis Patients
2022 · Tatiana D. Saccon, Joseph M. Dhahbi, et al. · Biology · 14
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Microbiome in aging of Gut and Brain (MiaGB): paving the ways to understand gut-brain axis in aging
2022 · Michal M. Masternak, Hariom Yadav · Aging Pathobiology and Therapeutics · 5
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miR-146a-5p modulates cellular senescence and apoptosis in visceral adipose tissue of long-lived Ames dwarf mice and in cultured pre-adipocytes
2021 · Allancer D. C. Nunes, Moritz Weigl, et al. · GeroScience · 36
Growth Hormone Signaling Shapes the Impact of Environmental Temperature on Transcriptomic Profile of Different Adipose Tissue Depots in Male Mice
2021 · Augusto Schneider, Berta Victoria, et al. · The Journals of Gerontology Series A · 5
Circulating microRNA profile in humans and mice with congenital GH deficiency
2021 · Tatiana D. Saccon, Augusto Schneider, et al. · Aging Cell · 24
Growth hormone increases DNA damage in ovarian follicles and macrophage infiltration in the ovaries
2021 · Tatiana D. Saccon, Monique T. Rovani, et al. · GeroScience · 14
Specific PIWI-Interacting RNAs and Related Small Noncoding RNAs Are Associated With Ovarian Aging in Ames Dwarf (df/df) Mice
2021 · Joseph M Dhahbi, Joe W Chen, et al. · The Journals of Gerontology Series A · 6
Senolytic Combination of Dasatinib and Quercetin Alleviates Intestinal Senescence and Inflammation and Modulates the Gut Microbiome in Aged Mice
2021 · Tatiana Dandolini Saccon, Ravinder Nagpal, et al. · The Journals of Gerontology Series A · 247
Skeletal muscle RBM3 expression is associated with extended lifespan in Ames Dwarf and calorie restricted mice
2020 · Zachary R. Hettinger, Amy L. Confides, et al. · Experimental Gerontology · 12
The Interconnections Between Somatic and Ovarian Aging in Murine Models
2020 · Augusto Schneider, Tatiana D Saccon, et al. · The Journals of Gerontology Series A · 18
17α-Estradiol Modulates IGF1 and Hepatic Gene Expression in a Sex-Specific Manner
2020 · Silvana Sidhom, Augusto Schneider, et al. · The Journals of Gerontology Series A · 24
Primordial follicle reserve, DNA damage and macrophage infiltration in the ovaries of the long-living Ames dwarf mice
2020 · Tatiana Dandolini Saccon, Monique Tomazele Rovani, et al. · Experimental Gerontology · 19
Dasatinib plus quercetin prevents uterine age-related dysfunction and fibrosis in mice
2020 · Marcelo B. Cavalcante, Tatiana D. Saccon, et al. · Aging · 80
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Growth hormone-mediated reprogramming of macrophage transcriptome and effector functions
2019 · Augusto Schneider, Hillary N. Wood, et al. · Scientific Reports · 29
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17α-Estradiol promotes ovarian aging in growth hormone receptor knockout mice, but not wild-type littermates
2019 · José V.V. Isola, Bianka M. Zanini, et al. · Experimental Gerontology · 21
The Role of Ames Dwarfism and Calorie Restriction on Gut Microbiota
2019 · Denise S Wiesenborn, Eric J C Gálvez, et al. · The Journals of Gerontology Series A · 18
Profiling of tRNA Halves and YRNA Fragments in Serum and Tissue From Oral Squamous Cell Carcinoma Patients Identify Key Role of 5′ tRNA-Val-CAC-2-1 Half
2019 · Joseph Dhahbi, Yury O. Nunez Lopez, et al. · Frontiers in Oncology · 25
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The enigmatic role of growth hormone in age-related diseases, cognition, and longevity
2019 · Gabriela Colon, Tatiana Saccon, et al. · GeroScience · 43
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Effect of caloric restriction and rapamycin on ovarian aging in mice
2019 · Driele N. Garcia, Tatiana D. Saccon, et al. · GeroScience · 93
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Self-Assembled STrap for Global Proteomics and Salivary Biomarker Discovery
2019 · Yi-Han Lin, Rodrigo Vargas Eguez, et al. · Journal of Proteome Research · 43
Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study
2019 · Jamie N. Justice, Anoop M. Nambiar, et al. · EBioMedicine · 1,261
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