Systematic Drug Repurposing Targeting Immune Activation Networks in Alzheimer's Disease (ad)
Description: Alzheimer's disease (AD) is an incurable neurodegenerative disease standing now as the sixth leading cause of death in the United States, and recent estimates expect the number of individuals affected by AD to more than triple by 2050. Recent genetic studies implicate a role for the immune system in onset and progression of AD, presenting new opportunities for developing therapeutics against AD. This project leverages recent insights from genetic studies and drug repurposing to identify established therapies that could be repurposed to meet the great unmet need for new and effective treatments targeting immune dysfunction in AD.
Funder: National Institute on Aging
Funding type: research
Funder scheme: RF1
Start date: 2018-07-15
End date: 2023-08-31
Investigator: MICHELLE E EHRLICH
Institution: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Funded outputs count: 72
Funder award ID: RF1AG059319
OpenAlex ID: G5491362581