Exercise Dose and Metformin for Vascular Health in Adults with Metabolic Syndrome
Description: PROJECT NARRATIVE/RELEVANCE Arterial vascular disease (including large to small peripheral vessels) is the major cause of morbidity and mortality in Metabolic Syndrome (MetS). We propose the first examination of pharmacology interaction with exercise training dose on improving baseline and insulin dependent vascular stiffness and function in middle- aged MetS patients. The proposed studies will define the role of pharmacology on optimal physical activity behavior to reverse clinical vascular and metabolic abnormalities as well as be the first effort to improve public health recommendations of physical activity when people are prescribed medication.
Funding type: research
Funder scheme: R01
Start date: 2017-02-01
End date: 2024-01-31
Investigator: STEVEN K MALIN (lead)
Institutions: Rutgers, The State University of New Jersey, RUTGERS, THE STATE UNIV OF N.J.
Funded outputs count: 71
Funder award ID: R01HL130296
OpenAlex ID: G7836235084