Elucidation of the molecular mechanism that suppresses senescence -Epigenomic regulation by metabolism-
Description: Recent aging studies have suggested that cellular senescence is deeply involved in individual aging. While cellular senescence in individuals functions as a cancer suppressor, the accumulation of senescent cells causes chronic inflammation in organs and tissues, leading to age-related diseases. Therefore, elucidation of the molecular mechanism that suppresses senescence has become an important issue in aging research. The purpose of this study was to clarify the molecular mechanism of inhibition of cellular senescence by a transcription factor ZHX3. Next-generation sequence analysis and knockout mouse analysis revealed that the transcription factor ZHX3 plays an important role in cellular senescence.
Amount: ¥4,160,000
Funding type: fellowship
Funder scheme: Grant-in-Aid for Early-Career Scientists
Start date: 2018-04-01
End date: 2022-03-31
Investigator: TOMOKA IGATA
Institution: Kumamoto University
Funded outputs count: 2
Funder award ID: 18K15048
OpenAlex ID: G7058757173