Effect of Metformin on Vascular and Mitochondrial Function in Type 1 Diabetes
Description: PUBLIC HEALTH RELEVANCE: Although blood sugar control in type 1 diabetes has improved dramatically over the last decades, cardiovascular disease incidence has not, and cardiovascular disease remains the primary cause of early mortality in this population. Recent trials suggest that we are approaching the limits of our ability to safely control blood sugars in diabetes. The proposed study uses an intervention expected to increase insulin sensitivity to investigate the effect of insulin sensitization on blood vessel function and mitochondrial health in type 1 diabetes. The results of these studies may identify new methods of managing type 1 diabetes specifically intended to improve cardiovascular outcomes.
Funding type: career_development
Funder scheme: K23
Start date: 2011-08-01
End date: 2015-07-31
Investigator: IRENE E SCHAUER
Institution: UNIVERSITY OF COLORADO DENVER
Funded outputs count: 3
Funder award ID: K23DK091553
OpenAlex ID: G2551835752