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Genetic Dissection of OXPHOS Assembly in Skeletal Muscles

Description: PROJECT NARRATIVE These studies will lead to fundamental new insights into the mechanism of OXPHOS assembly in muscles. In addition, it has the potential to identify novel regulators of OXPHOS assembly in muscle, that may open up therapeutic opportunities for many muscle mitochondrial diseases.
Funding type: research
Funder scheme: R21
Start date: 2020-04-01
End date: 2023-03-31
Investigator: EDWARD OWUSU-ANSAH
Institution: COLUMBIA UNIVERSITY HEALTH SCIENCES
Funded outputs count: 18
Funder award ID: R21AR077312
OpenAlex ID: G175559736
Phospholipids can regulate complex I assembly independent of their role in maintaining mitochondrial membrane integrity
2023 · Anjaneyulu Murari, Shauna-Kay Rhooms, et al. · Cell Reports · 6
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Using fruit flies to delve into mosquito insecticide resistance
2023 · Kaniz Fatima Binte Hossain, Divya Vimal, et al. · Frontiers in Malaria · 3
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Resting mitochondrial complex I from Drosophila melanogaster adopts a helix-locked state
2023 · Abhilash Padavannil, Anjaneyulu Murari, et al. · eLife · 25
The membrane domain of respiratory complex I accumulates during muscle aging in Drosophila melanogaster
2022 · Kaniz Fatima Binte Hossain, Anjaneyulu Murari, et al. · Scientific Reports · 4
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The mitochondrial calcium uniporter of pulmonary type 2 cells determines severity of acute lung injury
2022 · Mohammad Naimul Islam, Galina A. Gusarova, et al. · Nature Communications · 24
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IDH2-mediated regulation of the biogenesis of the oxidative phosphorylation system
2022 · Anjaneyulu Murari, Naga S. V. Goparaju, et al. · Science Advances · 24
A Ferroptosis-mediated regulation of the biogenesis of the oxidative phosphorylation system
2022 · Anjaneyulu Murari, Shauna Kay-Rhooms, et al. · bioRxiv (Cold Spring Harbor Laboratory)
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Analyzing the integrity of oxidative phosphorylation complexes in Drosophila flight muscles
2021 · Anjaneyulu Murari, Edward Owusu-Ansah · STAR Protocols · 8
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Quantification of NADH:ubiquinone oxidoreductase (complex I) content in biological samples
2021 · Fariha Ansari, Belem Yoval-Sánchez, et al. · Journal of Biological Chemistry · 23
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Dissecting the concordant and disparate roles of NDUFAF3 and NDUFAF4 in mitochondrial complex I biogenesis
2021 · Anjaneyulu Murari, Shauna-Kay Rhooms, et al. · iScience · 14
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Mitochondria in epithelial ovarian carcinoma exhibit abnormal phenotypes and blunted associations with biobehavioral factors
2021 · Snehal Bindra, Marlon A. McGill, et al. · Scientific Reports · 18
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The Mitochondrial Calcium Uniporter of Pulmonary Type 2 Cells Determines Severity of ARDS
2021 · Mohammad Naimul Islam, Galina A. Gusarova, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 3
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Mitochondrial Respiratory Chain Protein Co-Regulation in the Human Brain
2021 · Caroline Trumpff, Edward Owusu-Ansah, et al. · Heliyon · 7
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An antibody toolbox to track complex I assembly defines AIF’s mitochondrial function
2020 · Anjaneyulu Murari, Shauna-Kay Rhooms, et al. · The Journal of Cell Biology · 34
Circadian regulation of mitochondrial uncoupling and lifespan
2020 · Matt Ulgherait, Anna Chen, et al. · Nature Communications · 88
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Cyb5r3 links FoxO1-dependent mitochondrial dysfunction with β-cell failure
2020 · Jason Fan, Wen Du, et al. · Molecular Metabolism · 45
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Insights from Drosophila on mitochondrial complex I
2019 · Shauna-Kay Rhooms, Anjaneyulu Murari, et al. · Cellular and Molecular Life Sciences · 38
Progressive Methods in Data Warehousing and Business Intelligence: Concepts and Competitive Analytics
2009 · David Taniar · 11
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