Identification of infertile genes in aging mice using genome editing method
Description: The declining birth rates and aging population is occurring in advanced countries, including Japan, leading to an increase in late childbirth. Despite having eggs in their ovaries, elderly women are experiencing infertility, and understanding the mechanisms of ovulation disorders caused by aging is essential for addressing infertility. We discovered that the oxidative stress response pathway, activated during the early phase of the ovulation hormone response, is significantly reduced by analyzing the whole gene expression in the ovaries of aged mice at each sexual cycle. Based on this data, they conducted ovarian cell profiling analysis in aging mice and elucidated the genes and cells responsible for ovulation disorders. GONAD method, which enables simple generation of knockout mice through genome editing was used, and they clarified the mechanisms of ovulation disorders caused by aging.
Amount: ¥4,420,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2018-04-01
End date: 2023-03-31
Investigator: Yoichi Mizukami
Institution: Yamaguchi University
Subfield: Molecular Biology
Domain: Life Sciences
Funded outputs count: 31
Funder award ID: 18K11128
OpenAlex ID: G7155449107