Midlife Obesity, Neurovascular Senescence and Cognitive Decline
Description: Mid-life obesity leads to unhealthy/accelerated brain aging, exacerbating cognitive decline later in life. Yet, the impact of obesity-induced senescence on the cellular components of the neurovascular unit and its functions, including neurovascular coupling, maintenance of blood-brain barrier (BBB) integrity, and microcirculatory network architecture are not understood. Understanding the relationship between brain cellular senescence and impaired BBB function and diminished cerebrovascular hemodynamic responses (which are responsible to maintain intact cognitive function) will be critical to address potential nutritional interventional therapies to avoid obesity-induced cognitive deficits in aging.
Funder: National Institute on Aging
Funding type: career_development
Funder scheme: K01
Start date: 2021-08-01
End date: 2026-07-31
Investigator: STEFANO TARANTINI
Institution: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
Funded outputs count: 76
Funder award ID: K01AG073614
OpenAlex ID: G9000883650