Establishment of a novel research strategy for dietetics based on epigenomics (epigenome dietetics)
Description: Overintake of phosphate, which is an essential nutrient, has been concerned about the risk factor associated with cariovascular disease and all-cause mortality. In this study, we have explored a novel biomarker reflecting continuous overintake of phosphate in mice and validated the marker in human. We demonstrated that fibroblast growth factor 23 (FGF23), which is a phosphaturic hormone, can be a good biomarker reflecting continuous overintake of phosphate. In addition, we developed a convenient evaluation tool to assess the daily intake of phosphate in human. This tool and the marker, FGF23, are useful tool to determine adequate recommended dietary allowance of phosphate and for nutritional education in chronic kidney disease patients who are required dietary phosphate restriction.
Amount: ¥17,030,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (B)
Start date: 2016-04-01
End date: 2019-03-31
Investigator: Yutaka TAKETANI
Institution: The University of Tokushima
Funded outputs count: 10
Funder award ID: 16H03046
OpenAlex ID: G7307655859