Development of three-dimensional brain tissue engineering by the combination of angiogenesis and neurogenesis models
Description: The purpose of this study is to construct a culture model of neurovascular unit, which is a three-dimensional (3D) unit structure in the brain, by 3D culture in a microfluidic device from the standpoint of tissue engineering. This study was conducted by focusing on the development of an angiogenesis model, which was followed by the combination of the angiogenesis model and a neurogenesis model. First, we constructed a microfluidic device, which is a common culture platform for both angiogenesis and neurogenesis models. We then investigated an angiogenesis model which is useful in brain tissue engineering. Furthermore, we constructed a brain angiogenesis model by recapitulating brain developmental stages. Finally, we successfully constructed a 3D NVU culture model by combining angiogenesis and neurogenesis models.
Amount: ¥6,240,000
Funding type: research
Funder scheme: Grant-in-Aid for Challenging Research (Exploratory)
Start date: 2018-06-29
End date: 2020-03-31
Investigator: Ryo Sudo
Institution: Keio University
Funded outputs count: 7
Funder award ID: 18K19937
OpenAlex ID: G7338288018