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Relationship between sarcopenic obesity and changes in adipokine secretion from adipose tissues with aging

Description: In the super-aging society, the increase in the incidence of age-related diseases such as sarcopenic obesity becomes a problem. To elucidate the pathogenic mechanisms of sarcopenic obesity, the relationship of inhibition of myogenic differentiation with promotion of adipogenic differentiation by the interaction between adipocytes and myoblasts was examined in the study. The expression levels of adipokines in adipose tissues increased with aging and were influenced by immunocytes, not by adipocytes. Myogenic differentiation was controlled by insulin-like growth factor expression.

Funder: Japan Society for the Promotion of Science

Amount: ¥3,510,000

Funding type: research

Funder scheme: Grant-in-Aid for Challenging Exploratory Research

Start date: 2016-04-01

End date: 2018-03-31

Investigator: Hidemi Hattori

Institution: University of Miyazaki

Topic: Adipokines, Inflammation, and Metabolic Diseases

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

Funded outputs count: 0

Funder award ID: 16K13061

OpenAlex ID: G7367707087