Mechanism of autophagy activation in exercise-induced anti-diabetic benefits
Description: Project Narrative Physical exercise exerts beneficial effects against type 2 diabetes (T2D), but the mechanisms by which exercise induces systemic metabolic benefits are unclear. We recently discovered that activation of autophagy, a lysosomal degradation pathway, in non-contractile tissues during exercise, via exercise-stimulated muscle-secreted fibronectin (Fn1) and downstream pathways, may play an important role in the regulation of exercise-induced insulin sensitization. In this proposal, we will demonstrate the role and mechanism of autophagy activation in non-contractile tissues in driving exercise-induced metabolic benefits against T2D.
Funding type: research
Funder scheme: R01
Start date: 2017-09-12
End date: 2026-07-31
Investigator: CONGCONG HE
Institution: NORTHWESTERN UNIVERSITY
Funded outputs count: 20
Funder award ID: R01DK113170
OpenAlex ID: G9000867166