Clock-Driven Sleep Fragmentations in Tauopathy
Description: In Aim 1, we will evaluate how inactivation states of voltage-gated sodium channels alter tau proteostasis, core clock system regulation, and circadian activity. In Aim 2, we will investigate the effect of pharmacological manipulations of inactivation states of voltage-gated sodium channels on clock neuron electrophysiology, sleep behavior, cognition, and lifespan in the adult Drosophila brain. In Aim 3, we will demonstrate that the inactivation states of voltage-gated sodium channels are altered in the iPS cells derived from human patients.
Funder: BrightFocus Foundation
Amount: $300,000
Funding type: research
Funder scheme: Alzheimer's Disease Research: Standard
Start date: 2021-07-01
End date: 2025-06-30
Investigators: Masashi Tabuchi, Masashi Tabuchi
Institution: Case Western Reserve University School of Medicine
Funded outputs count: 6
Funder award ID: A2021043S
OpenAlex ID: G7466601923