Mitochondrial Protection to Derive Expanded Aged Renal Glomerular Progenitor Cells
Description: The kidneys of aging adults have increased susceptibility to renal injury from insults such as opportunistic infections, diabetes, and high fat diets and even from therapeutic interventions such as chemotherapy or surgery. Autologous stem cell transplant is rapidly evolving as a potential therapeutic to restore resiliency to aging kidneys, particularly in response to acute injury resulting from therapeutic intervention. With this proposal we ask the fundamental question in mice and humans: can reduction of aging mitochondrial dysfunction in vitro restore the expansion, survival and progenitor potential of aged urine-derived progenitor cells?
Funder: National Institute on Aging
Funding type: career_development
Funder scheme: K01
Start date: 2019-07-15
End date: 2025-03-31
Investigator: MARIYA TS'ANA SWEETWYNE
Institution: UNIVERSITY OF WASHINGTON
Funded outputs count: 22
Funder award ID: K01AG062757
OpenAlex ID: G1910631688