Get started
Award

干细胞衰老的表观遗传调控机制

Funding type: grant
Start date: 2021-01-01
Investigator: 高绍荣 (lead)
Institutions: Tongji University, 同济大学
Funded outputs count: 18
Funder award ID: 21JC1405500
OpenAlex ID: G746818793
ROCK inhibition suppresses host blastomere-mediated elimination and enhances trophoblast stem cell contribution in mouse chimeras
2026 · Baoxing Dong, Kuisheng Liu, et al. · Stem Cell Reports
Grtp1 Safeguards Against Paternal Reproductive Aging and Intergenerational Behavioral Deficits by Preserving Redox Homeostasis
2026 · Yingdong Liu, Shanyao Liu, et al. · Advanced Science
PDF
Generating LGE/CGE Organoids from Human Pluripotent Stem Cell-derived Brain Organoids Without External Signal Induction
2026 · Xiaojin Zhu, Zhile Bai, et al. · Cell Reports
Optimized derivation and culture system of human naïve pluripotent stem cells with enhanced DNA methylation status and genomic stability
2025 · Yan Bi, Jindian Hu, et al. · Protein & Cell · 4
Intercellular crosstalk within human preimplantation lineages regulates trophectoderm specification
2025 · Zhifen Tu, Yan Bi, et al. · 中国科学通报：英文版 · 1
Persistent Wnt signaling affects IVF embryo implantation and offspring metabolism
2025 · Yanping Jia, Yingdong Liu, et al. · 中国科学通报：英文版 · 10
RNA m 6 A modification regulates cell fate transition between pluripotent stem cells and 2‐cell‐like cells
2024 · Zhongqu Su, Yu Dong, et al. · Cell Proliferation · 5
Defining a TFAP2C-centered transcription factor network during murine peri-implantation
2024 · Rui Gao, Guang Yang, et al. · Developmental Cell · 22
ISR inhibition reverses pancreatic β-cell failure in Wolfram syndrome models
2024 · Rui Hu, Xiangyi Chen, et al. · Cell Death and Differentiation · 16
PDF
Unreprogrammed H3K9me3 prevents minor zygotic genome activation and lineage commitment in SCNT embryos
2023 · Ruimin Xu, Qianshu Zhu, et al. · Nature Communications · 35
PDF
Inhibition of Wnt activity improves peri-implantation development of somatic cell nuclear transfer embryos
2023 · Yanhe Li, Caihong Zheng, et al. · National Science Review · 17
PDF
Induction and application of human naive pluripotency
2023 · Jianfeng Zhou, Jindian Hu, et al. · Cell Reports · 44
PDF
LSM1-mediated Major Satellite RNA decay is required for nonequilibrium histone H3.3 incorporation into parental pronuclei
2023 · Jiang Zhu, Kang Chen, et al. · Nature Communications · 10
PDF
Remodeling of H3K9me3 during the pluripotent to totipotent-like state transition
2023 · Hu Li, Jiatong Sun, et al. · Stem Cell Reports · 10
Modeling human pregastulation development by 3D culture of blastoids generated from primed-to-naïve transitioning intermediates
2022 · Zhifen Tu, Yan Bi, et al. · Protein & Cell · 26
PDF
Mettl14-driven senescence-associated secretory phenotype facilitates somatic cell reprogramming
2022 · Chenxiang Xi, Jiatong Sun, et al. · Stem Cell Reports · 17
Stage-specific H3K9me3 occupancy ensures retrotransposon silencing in human pre-implantation embryos
2022 · Ruimin Xu, Sen Li, et al. · Cell stem cell · 122
Aberrant nucleosome organization in mouse SCNT embryos revealed by ULI-MNase-seq
2022 · Lingyue Yang, Xiaocui Xu, et al. · Stem Cell Reports · 7
Cell fate roadmap of human primed-to-naive transition reveals preimplantation cell lineage signatures
2022 · Yan Bi, Zhifen Tu, et al. · Nature Communications · 37
PDF
Aberrant H3K4me3 modification of epiblast genes of extraembryonic tissue causes placental defects and implantation failure in mouse IVF embryos
2022 · Dandan Bai, Jin Sun, et al. · Cell Reports · 31