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Epicardial remodeling in cardiomyopathy and cardiac aging

Description: Project Narrative This proposal aims to leverage the efficient zebrafish and killifish models to decipher functions of epicardium in cardiomyopathy and cardiac aging, aiming to develop an anti-aging-based therapy.
Funding type: research
Funder scheme: R01
Start date: 2011-04-01
End date: 2029-02-28
Investigator: XIAOLEI XU
Institution: MAYO CLINIC ROCHESTER
Funded outputs count: 59
Funder award ID: R01HL107304
OpenAlex ID: G9000892360
A single-cell RNA sequencing dataset of cardiac aging in African Turquoise Killifish
2026 · Baul Yoon, Yifeng Xu, et al. · Scientific Data
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From Computational Prediction to In Vivo Experimental Validation: A Translational AI Pipeline for Anthracycline-Induced Cardiotoxicity
2026 · Manqi Li, Jing Wei, et al. · Research Square
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An mTOR ‐Tfeb‐Fabp7a Axis Ameliorates bag3 Cardiomyopathy via Decelerating Cardiac Aging
2025 · Yonghe Ding, Xueling Ma, et al. · Aging Cell · 3
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Deregulated nutrient response in ttntv cardiomyopathy can be repaired via Erk inhibition for cardioprotective effects
2025 · Feixiang Yan, Weiyue Wang, et al. · Journal of Molecular and Cellular Cardiology
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Nothobranchius furzeri: a vertebrate model for studying cardiac aging and cellular senescence
2025 · Xueling Ma, Yonghe Ding, et al. · npj Aging · 12
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An Intraperitoneal Injection Technique in Adult Zebrafish that Minimizes Body Damage and Associated Mortality
2024 · Maryam Moossavi, Hong Zhang, et al. · Journal of Visualized Experiments · 7
Allelic heterogeneity of TTNtv dilated cardiomyopathy can be modeled in adult zebrafish
2024 · Ping Zhu, Jiarong Li, et al. · JCI Insight · 5
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Assessing Cardiac Functions of Zebrafish from Echocardiography Using Deep Learning
2023 · Mao-Hsiang Huang, Amir Mohammad Naderi, et al. · Information · 5
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Molecular mechanisms of anthracycline induced cardiotoxicity: Zebrafish come into play
2023 · Maryam Moossavi, Xiaoguang Lu, et al. · Frontiers in Cardiovascular Medicine · 4
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Transcriptome studies of inherited dilated cardiomyopathies
2023 · Matthew Koslow, David Mondaca-Ruff, et al. · Mammalian Genome · 7
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Genetic therapy in a mitochondrial disease model suggests a critical role for liver dysfunction in mortality
2022 · Ankit Sabharwal, Mark D Wishman, et al. · eLife · 9
A phenotype-based forward genetic screen identifies Dnajb6 as a sick sinus syndrome gene
2022 · Yonghe Ding, Di Lang, et al. · eLife · 14
Application of an F0-based genetic assay in adult zebrafish to identify modifier genes of an inherited cardiomyopathy
2022 · Yonghe Ding, Mingmin Wang, et al. · Disease Models & Mechanisms · 21
Genetic Susceptibility and Mechanisms Underlying the Pathogenesis of Anthracycline‐Associated Cardiotoxicity
2022 · Yonghe Ding, Ke Du, et al. · Oxidative Medicine and Cellular Longevity · 27
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Inhibition of mTOR or MAPK ameliorates vmhcl/myh7 cardiomyopathy in zebrafish
2021 · Haisong Bu, Yonghe Ding, et al. · JCI Insight · 40
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A novel wireless ECG system for prolonged monitoring of multiple zebrafish for heart disease and drug screening studies
2021 · Tai Le, Jimmy Zhang, et al. · Biosensors and Bioelectronics · 18
Changes in ion channel expression and function associated with cardiac arrhythmogenic remodeling by Sorbs2
2021 · Ling-Ling Qian, Xiaojing Sun, et al. · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 15
atg7 -Based Autophagy Activation Reverses Doxorubicin-Induced Cardiotoxicity
2021 · Yong Wang, Xiaoguang Lu, et al. · Circulation Research · 103
A Novel Art of Electrocardiogram Assessment in Zebrafish for Cardiovascular Disease Studies and Drug Screening
2021 · Tai Le, Jimmy Zhang, et al. · bioRxiv (Cold Spring Harbor Laboratory)
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Deep learning-based framework for cardiac function assessment in embryonic zebrafish from heart beating videos
2021 · Amir Mohammad Naderi, Haisong Bu, et al. · Computers in Biology and Medicine · 26
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TFEB Overexpression, Not mTOR Inhibition, Ameliorates RagCS75Y Cardiomyopathy
2021 · Maengjo Kim, Linghui Lu, et al. · International Journal of Molecular Sciences · 32
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A Swimming-based Assay to Determine the Exercise Capacity of Adult Zebrafish Cardiomyopathy Models
2021 · Xiao Ma, Xiaolei Xu · BIO-PROTOCOL · 5
Modeling Inherited Cardiomyopathies in Adult Zebrafish for Precision Medicine
2020 · Yonghe Ding, Haisong Bu, et al. · Frontiers in Physiology · 21
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Knockout of SORBS2 Protein Disrupts the Structural Integrity of Intercalated Disc and Manifests Features of Arrhythmogenic Cardiomyopathy
2020 · Yonghe Ding, Jingchun Yang, et al. · Journal of the American Heart Association · 39
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Building the vertebrate codex using the gene breaking protein trap library
2020 · Noriko Ichino, MaKayla R Serres, et al. · eLife · 15
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