Perturbation based single cell investigation of tumor micro-environment
Description: Project Narrative Glioblastoma is the most aggressive and common form of primary brain cancer with a median patient survival time of ~ 15 months. Professor Luis Parada at Sloan Kettering Cancer Institute have established the mouse model and faithfully phenocopy the tumor genesis. This proposal will use single cell RNAseq, single cell ATACseq and multi-photon imaging to probe tissue stem cell and cancer initiation cell transcriptional regulation network, heterogeneity and immune privilege.
Funder: National Cancer Institute
Funding type: career_development
Funder scheme: K00
Start date: 2020-08-03
End date: 2026-07-31
Investigator: CHI ZHANG
Institution: DANA-FARBER CANCER INST
Funded outputs count: 1
Funder award ID: K00CA253738
OpenAlex ID: G9000894896