Biological Aging Across the Life Course: Harmonizing Cohort Biospecimen Archives
Description: Aging blood-based biomarkers (assays: IL-6, TNFa, CRP, GDF15, IGF-1, Cystatin C, NT-proBNP, and hbA1c), DNA methylation (Illumina EPIC chip), and gene expression (RNA Seq) provide an opportunity to detect aging related diseases and identify mechanisms linking earlier exposures to later life health. However, little is known about how these aging biomarkers correlate with each other, the environment, or health over the life course. This project uses data from three large nationally representative panel studies to examine these associations over the life course: the Health and Retirement Study (biomarker data for ages 51-110), the National Longitudinal Study of Adolescent to Adult Health (biomarker data ages 24-42) and the Fragile Families and Child Wellbeing Study (biomarker data ages 9-22).
Funder: National Institute on Aging
Funding type: research
Funder scheme: R01
Start date: 2021-03-15
End date: 2027-02-28
Investigator: JESSICA FAUL
Institution: UNIVERSITY OF MICHIGAN AT ANN ARBOR
Funded outputs count: 25
Funder award ID: R01AG071071
OpenAlex ID: G9000857118