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Identification of Non-Invasive Biomarkers and Indices for Diagnosis of Drug-Induced Acute Interstitial Nephritis

Description: PROJECT NARRATIVE Drug-induced acute interstitial nephritis results from immune-mediated kidney injury triggered by commonly used drugs and leads to chronic kidney disease. Since there is no reliable non-invasive diagnostic test, the diagnosis of drug-induced acute interstitial nephritis currently requires a kidney biopsy. In this study, the candidate will use biosamples and data from patients with acute interstitial nephritis to identify biomarkers and create indices to diagnose this disease, which will improve clinical care of patients with suspected acute interstitial nephritis and reduce the burden of chronic kidney disease. ! !
Funding type: career_development
Funder scheme: K23
Start date: 2018-09-11
End date: 2024-07-31
Investigator: DENNIS G. MOLEDINA
Institution: YALE UNIVERSITY
Field: Medicine
Funded outputs count: 50
Funder award ID: K23DK117065
OpenAlex ID: G7505407285
Concordance of Prebiopsy and Postbiopsy Diagnosis in Hospitalized Patients with Acute Kidney Injury
2026 · Maxine McGredy, David Hu, et al. · Kidney360 · 1
Extracellular Vesicles From Chylomicron-Treated Endothelial Cells Drive Macrophage Inflammation
2025 · Anna Tilp, Dimitrios Nasias, et al. · Arteriosclerosis Thrombosis and Vascular Biology · 7
Biomarker Panels for Predicting Progression of Kidney Disease in Acute Kidney Injury Survivors
2024 · Steven Menez, Kathleen F. Kerr, et al. · Clinical Journal of the American Society of Nephrology · 7
External Validation of an Electronic Health Record–Based Diagnostic Model for Histological Acute Tubulointerstitial Nephritis
2024 · Dennis G. Moledina, Kyra Shelton, et al. · Journal of the American Society of Nephrology · 4
Plasma proteomics of acute tubular injury
2024 · Insa M. Schmidt, Aditya L. Surapaneni, et al. · Nature Communications · 19
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Urinary Plasminogen as a Marker of Disease Progression in Human Glomerular Disease
2024 · Marina de Cos, Gohar Mosoyan, et al. · American Journal of Kidney Diseases · 5
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Rationale and Design of a Phase 2, Double-blind, Placebo-Controlled, Randomized Trial Evaluating AMP Kinase-Activation by Metformin in Focal Segmental Glomerulosclerosis
2024 · Gabriel C. Barsotti, Randy Luciano, et al. · Kidney International Reports · 3
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APOBEC-1 deletion enhances cisplatin-induced acute kidney injury
2023 · Xiaojia Guo, Valerie Blanc, et al. · Scientific Reports · 3
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Urinary Biomarkers and Kidney Injury in VA NEPHRON-D: Phenotyping Acute Kidney Injury in Clinical Trials
2023 · Elizabeth A. Kiernan, David Hu, et al. · American Journal of Kidney Diseases · 8
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The ASSESS-AKI Study found urinary epidermal growth factor is associated with reduced risk of major adverse kidney events
2023 · Steven Menez, Yumeng Wen, et al. · Kidney International · 31
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Identification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis
2023 · Dennis G. Moledina, Wassim Obeid, et al. · Journal of Clinical Investigation · 80
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Evaluation of Plasma Biomarkers to Predict Major Adverse Kidney Events in Hospitalized Patients With COVID-19
2023 · Steven Menez, Steven G. Coca, et al. · American Journal of Kidney Diseases · 15
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Longitudinal biomarkers and kidney disease progression after acute kidney injury
2023 · Yumeng Wen, Leyuan Xu, et al. · JCI Insight · 70
Pre-operative kidney biomarkers and risks for death, cardiovascular and chronic kidney disease events after cardiac surgery: the TRIBE-AKI study
2022 · George Vasquez-Rios, Dennis G. Moledina, et al. · Journal of Cardiothoracic Surgery · 14
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Safety and Adequacy of Kidney Biopsy Procedure in Patients with Obesity
2022 · Long Qian, Steven Menez, et al. · Kidney360 · 5
Immune-mediated tubule atrophy promotes acute kidney injury to chronic kidney disease transition
2022 · Leyuan Xu, Jiankan Guo, et al. · Nature Communications · 93
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Urine Uromodulin as a Biomarker of Kidney Tubulointerstitial Fibrosis
2022 · Hannah Melchinger, Frida Calderon-Gutierrez, et al. · Clinical Journal of the American Society of Nephrology · 39
Immune checkpoint inhibitors and kidney disease
2022 · Qiyu Wang, Dennis G. Moledina, et al. · Current Opinion in Nephrology & Hypertension · 6
Considerations in Controlling for Urine Concentration for Biomarkers of Kidney Disease Progression After Acute Kidney Injury
2022 · Yumeng Wen, Heather Thiessen-Philbrook, et al. · Kidney International Reports · 27
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Pre-Operative Kidney Biomarkers and Risks for Death, Cardiovascular and Chronic Kidney Disease Events after Cardiac Surgery: The TRIBE-AKI Study
2022 · Chirag R. Parikh, George Vasquez-Rios, et al. · Research Square
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Urine testing to differentiate glomerular from tubulointerstitial diseases on kidney biopsy
2022 · Anna C. Tran, Hannah Melchinger, et al. · Practical Laboratory Medicine · 7
Clinically adjudicated deceased donor acute kidney injury and graft outcomes
2022 · Sherry G. Mansour, Nadeen Khoury, et al. · PLoS ONE · 10
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Mortality after acute kidney injury and acute interstitial nephritis in patients prescribed immune checkpoint inhibitor therapy
2022 · Megan L Baker, Yu Yamamoto, et al. · Journal for ImmunoTherapy of Cancer · 42
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Development and external validation of a diagnostic model for biopsy-proven acute interstitial nephritis using electronic health record data
2021 · Dennis G Moledina, Michael T Eadon, et al. · Nephrology Dialysis Transplantation · 26
Plasma Soluble Tumor Necrosis Factor Receptor Concentrations and Clinical Events After Hospitalization: Findings From the ASSESS-AKI and ARID Studies
2021 · Steven G. Coca, George Vasquez-Rios, et al. · American Journal of Kidney Diseases · 21
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