Elucidation of the molecular mechanism and regulation of T-cell senescence
Description: Accumulation of fat in visceral adipose tissue causes chronic inflammation due to infiltration of immune cells, mainly macrophages. We have found that osteopontin secreted by senescent T cells is involved in chronic inflammation in visceral adipose tissue. In the present study, we found that removal of senescent T cells by targeting PD-1 (Programmed cell death protein 1) improves glucose metabolism. This method would also remove activated T cells, which is not desirable. Regulation of transcriptional activity of osteopontin is important as a therapeutic target. We have been trying to clarify the mechanism of activation and regulation of the transcriptional activity of osteopontin, which is observed not only in visceral obesity but also in myocardial infarction and diabetic kidney disease.
Amount: ¥17,420,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (B)
Start date: 2018-04-01
End date: 2021-03-31
Investigator: Motoaki SANO
Institution: Keio University
Funded outputs count: 13
Funder award ID: 18H02812
OpenAlex ID: G7520035128