The effect of white matter hyperintensity volume on cognition, depressive symptoms, and regional cerebral blood flow in mild cognitive impairment
Description: The Objective of this study was to investigate the association between white matter hyperintensities (WMH) progression and cognitive decline in amnestic mild cognitive impairment (MCI).Thirty-eight subjects with MCI were analyzed prospectively every year for 2 years. Fourteen MCI subjects dropped out on the final visit, and therefore 24 subjects with MCI were analyzed for the entire duration. The volumes of periventricular hyperintensities (PVH) and deep WMH (DWMH) were measured on T2 FLAIR using the 3D-slicer. The associations between PVH/DWMH progression and cognitive decline were investigated. An increase in DWMH volume significantly correlated with changes in MMSE and category verbal fluency scores. DWMH progression was closely associated with a decline in frontal lobe function and semantic memory, suggesting that WMH progression might affect some Alzheimer's disease (AD) pathophysiologies in MCI patients.
Amount: ¥4,160,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2017-04-01
End date: 2022-03-31
Investigator: Kentaro Hirao
Institution: Tokyo Medical University
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Funded outputs count: 3
Funder award ID: 17K09327
OpenAlex ID: G7556533673