Award

Defining the role of cellular senescence in osteoarthritis

Description: PUBLIC HEALTH RELEVANCE: Osteoarthritis (OA) is a common cause of joint pain and disability in the elderly, and a form of age- associated cellular dysfunction known as senescence may be involved. This project will use genetically engineered mice to track the development of cellular senescence with aging and joint injury, and will also assess the effect of preventing chondrocyte senescence on the development of OA. The long-term goal of this training fellowship is to generate novel strategies for treating or preventing OA, and to provide extensive training in the techniques required for the principle investigator to continue research in the area of cartilage aging.

Funder: National Institute on Aging

Funding type: fellowship

Funder scheme: F32

Start date: 2015-04-01

End date: 2018-03-31

Investigator: BRIAN O DIEKMAN

Institution: UNIV OF NORTH CAROLINA CHAPEL HILL

Topic: Osteoarthritis Treatment and Mechanisms

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

Funded outputs count: 6