The mechanism for the generation of theta-rhythm synchronization between the gastatory and gastrointestinal insular corticies
Description: It was found that various functions occur as a result of the oscillatory synchronization between the two neuronal populations in the gustatory and its caudal gastrointestinal insular cortices and between those in the gustatory and its rostral pain insular cortices. CB1 receptor activation in the gustatory insular cortex causes oscillatory synchronization at theta rhythm between the two neuronal populations in the gustatory and gastrointestinal insular cortices, which would lead to overeating sweet and umami taste foods. Delta rhythm oscillatory synchronization would occur during taste aversion learning, resulting in unbalanced diet. In addition, it was clarified that activity of GABAergic neurons may be involved in delta rhythm generation while theta rhythm was not affected by the blockade of GABA receptors. Furthermore, it was revealed that a 24-hour fasting suppressed the second phase of the formalin-induced pain response through the activation of CB1 receptors.
Amount: ¥4,940,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2017-04-01
End date: 2022-03-31
Investigator: Youngnam Kang
Institution: Osaka University(2018-2021)Kagoshima University(2017)
Funded outputs count: 6
Funder award ID: 17K07055
OpenAlex ID: G7630453547