Excessive lipid metabolism in T cell senescence and immunosuppression
Description: PROJECT NARRATIVE The proposed studies address the important issue of immune suppression and dysfunction of tumor-reactive T cells in the tumor microenvironment that is a major barrier for successful anti-tumor immunity and immunotherapy. The proposed research has relevance to public health, because it seeks to dissect a novel suppressive mechanism and then to develop critical strategies that control immune suppression and T cell dysfunction. Thus, the findings are ultimately expected to be applicable to improve the treatments against human cancers and other diseases as well.
Funding type: research
Funder scheme: R01
Start date: 2023-08-03
End date: 2028-07-31
Investigator: GUANGYONG PENG
Institution: WASHINGTON UNIVERSITY
Funded outputs count: 6
Funder award ID: R01AI173260
OpenAlex ID: G9000897884