Development of synthetic strategies towards bioactive polycyclic natural products via catalytic radical cascade transformations
Description: In the present study, we developed new radical cascade reactions that feature environmentally-benign catalytic chemical transformations with high energy efficiency to produce polycyclic organic molecules. In addition, we devised synthetic routes to bioactive natural products based on the radical cascade reactions; 1) the formal total synthesis of antiviral marine natural product hamigeran B was accomplished by a visible-light-mediated radical cascade transformation; 2) a new means for accessing a hydroxybenzofuran from an alkynylquinone under quinone-hydroquinone organic redox conditions was developed, enabling the total synthesis of liphagal, a natural PI3kα inhibitor.
Amount: ¥4,290,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2018-04-01
End date: 2022-03-31
Investigator: Takehiko Yoshimitsu
Institution: Okayama University
Funded outputs count: 9
Funder award ID: 18K06578
OpenAlex ID: G7658642787