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Epigenetics of Arteriosclerosis in African American Hypertensive Sibships

Description: Narrative: In this project we will use state-of-the-art epigenome-wide data to identify people who are predisposed to developing damage to the kidneys, heart, brain, and peripheral arteries as a result of arteriosclerosis.
Funding type: research
Funder scheme: R01
Start date: 2016-07-01
End date: 2021-04-30
Investigator: JENNIFER ANN SMITH
Institution: UNIVERSITY OF MICHIGAN AT ANN ARBOR
Funded outputs count: 48
Funder award ID: R01HL133221
OpenAlex ID: G4152088415
Methylome-wide association analyses of lipids and modifying effects of behavioral factors in diverse race and ethnicity participants
2025 · Yao Hu, Jeff Haessler, et al. · Clinical Epigenetics · 1
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Multi-Ancestry Transcriptome-Wide Association Studies of Cognitive Function, White Matter Hyperintensity, and Alzheimer’s Disease
2025 · Dima L. Chaar, Zheng Li, et al. · International Journal of Molecular Sciences · 5
Neighborhood environment associations with cognitive function and structural brain measures in older African Americans
2025 · Dima L. Chaar, Le Tu, et al. · BMC Medicine · 4
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Association analysis between an epigenetic alcohol risk score and blood pressure
2024 · Helena Bui, Amena Keshawarz, et al. · Clinical Epigenetics · 3
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Methylation patterns associated with C-reactive protein in racially and ethnically diverse populations
2024 · Jessica I. Lundin, Ulrike Peters, et al. · Epigenetics · 10
meQTL mapping in the GENOA study reveals genetic determinants of DNA methylation in African Americans
2023 · Lulu Shang, Wei Zhao, et al. · Nature Communications · 42
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Epigenome-Wide Meta-Analysis Reveals Differential DNA Methylation Associated With Estimated Glomerular Filtration Rate Among African American Men With HIV
2023 · Junyu Chen, Qin Hui, et al. · Kidney International Reports · 7
Epigenome‐wide association study of BMI in Black populations from InterGEN and GENOA
2022 · Jacquelyn Y. Taylor, Yunfeng Huang, et al. · Obesity · 11
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Opioid Medication Use and Blood Dna Methylation: Epigenome-Wide Association Meta-Analysis
2022 · Mikyeong Lee, Roby Joehanes, et al. · Epigenomics · 12
SNP-by-CpG Site Interactions in ABCA7 Are Associated with Cognition in Older African Americans
2022 · Dima L. Chaar, Kim Nguyen, et al. · Genes · 5
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The Interplay of Epigenetic, Genetic, and Traditional Risk Factors on Blood Pressure: Findings from the Health and Retirement Study
2022 · Xinman Zhang, Farah Ammous, et al. · Genes · 10
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Differentially Methylated DNA Regions and Left Ventricular Hypertrophy in African Americans: A HyperGEN Study
2022 · Alana C. Jones, Amit Patki, et al. · Genes · 5
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METRO: Multi-ancestry transcriptome-wide association studies for powerful gene-trait association detection
2022 · Zheng Li, Wei Zhao, et al. · The American Journal of Human Genetics · 34
Epigenetics of single-site and multi-site atherosclerosis in African Americans from the Genetic Epidemiology Network of Arteriopathy (GENOA)
2022 · Farah Ammous, Wei Zhao, et al. · Clinical Epigenetics · 20
Genetic determinants of telomere length from 109,122 ancestrally diverse whole-genome sequences in TOPMed
2022 · Margaret A. Taub, Matthew P. Conomos, et al. · Cell Genomics · 82
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Epigenome-wide association study of mitochondrial genome copy number
2021 · Penglong Wang, Christina A Castellani, et al. · Human Molecular Genetics · 14
Transcriptome-Wide Association Study of Blood Cell Traits in African Ancestry and Hispanic/Latino Populations
2021 · Jia Wen, Munan Xie, et al. · Genes · 19
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Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging
2021 · Daniel L. McCartney, Josine L. Min, et al. · Genome biology · 295
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A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids
2021 · Min-A Jhun, Michael Mendelson, et al. · Nature Communications · 44
Accelerated DNA methylation age and medication use among African Americans
2021 · Minjung Kho, Yi Zhe Wang, et al. · Aging · 27
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Epigenetic age acceleration is associated with cardiometabolic risk factors and clinical cardiovascular disease risk scores in African Americans
2021 · Farah Ammous, Wei Zhao, et al. · Clinical Epigenetics · 102
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Novel DNA methylation signatures of tobacco smoking with trans-ethnic effects
2021 · C. Christiansen, J. E. Castillo-Fernandez, et al. · Clinical Epigenetics · 83
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Epigenome-wide association study identifies DNA methylation sites associated with target organ damage in older African Americans
2020 · Farah Ammous, Wei Zhao, et al. · Epigenetics · 19
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Epigenetic loci for blood pressure are associated with hypertensive target organ damage in older African Americans from the genetic epidemiology network of Arteriopathy (GENOA) study
2020 · Minjung Kho, Wei Zhao, et al. · BMC Medical Genomics · 23
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Leveraging gene co-expression patterns to infer trait-relevant tissues in genome-wide association studies
2020 · Lulu Shang, Jennifer A. Smith, et al. · PLoS Genetics · 38
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