Structural, Molecular and Functional Specialization in Osteocyte Mechanosensing
Description: PROJECT NARRATIVE As the mechanosensing cells of bone. osteocytes orchestrate a large repertoire of bone functions including bone modeling, remodeling and loss; the precise mechanisms through which they accomplish this sensing task remain unresolved. Our group has discovered that the osteocyte cell processes, i.e., the “fingers” of the osteocytes, function as unique and uniquely sensitive mechanosensory elements. In the current studies, we will explore how this remarkable mechanical sensing occurs which may open a new window for novel therapeutic targets that to modulate bone remodeling and prevent osteoporosis and bone fragility.
Funding type: research
Funder scheme: R01
Start date: 2018-07-11
End date: 2026-04-30
Investigator: MITCHELL B SCHAFFLER
Institution: CITY COLLEGE OF NEW YORK
Funded outputs count: 17
Funder award ID: R01AR070547
OpenAlex ID: G494390783