Sex differences in skeletal muscle stem cells
Description: Aging is associated with sarcopenia, which is defined by reductions in skeletal muscle mass, strength, and physical function. Sarcopenia decreases the ability to perform activities of daily living, reduces quality of life, and increases fall-risk and associated injuries. Older women exhibit greater frailty and skeletal muscle mass and strength losses compared to that in older men. It is likely that the underlying causes of sarcopenia are different in women and men, which will require the identification of sex-specific therapeutic targets.Skeletal muscles are generally considered to have high regenerative capacity. However, muscle regeneration capacity progressively declines with aging. Satellite cells are a group of adult muscle stem cells that play a key role in mediating muscle regeneration. Recent studies have shown that satellite cells progressively undergo sex-specific changes in cell-intrinsic characteristics and functions.
Amount: ¥17,160,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (B)
Start date: 2016-04-01
End date: 2019-03-31
Investigator: Shuichi Machida
Institution: Juntendo University
Funded outputs count: 18
Funder award ID: 16H03205
OpenAlex ID: G769865466