Mechanisms controlling distinct growth and functional characteristics of the perinatal and adult thymus
Description: Narrative The neonatal thymus microenvironment consists of multiple stromal cell types which are critical for the development of T cells that protect newborns from infectious diseases and autoimmunity. The cellular and molecular differences between neonatal and adult thymic stromal cells and the mechanisms regulating the transition from neonatal thymus growth to adult homeostasis are not understood. This program project will use single cell RNA sequencing, advanced imaging and other cutting edge approaches to identify cellular and molecular changes in stromal cell subsets in the mouse and human thymus during the neonatal to adult transition, determine the molecular pathways that regulate these changes and evaluate the ensuing effects on T cell function.
Funding type: program
Funder scheme: P01
Start date: 2020-09-01
End date: 2025-08-31
Investigator: ELLEN R RICHIE
Institution: UNIVERSITY OF TX MD ANDERSON CAN CTR
Funded outputs count: 31
Funder award ID: P01AI139449
OpenAlex ID: G1180573013