Epigenetic changes in hematopoietic system during aging and molecular basis of hematopoietic tumor
Description: To explore the difference in hematopoietic system during aging and clarify the pathogenicsignificance in hematopoietic disease, we perform RNA-seq and ATAC-seq using hematopoietic stem and progenitor cells to evaluate the differentially expressed genes and differentially accessible regions respectively. The results showed that many transcription factor networks has been changed during aging, indicating that the history of exposure to external stresses are epigenetically inscribed in HSCs to augment their responses to subsequent stimuli.
Amount: ¥4,420,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2018-04-01
End date: 2021-03-31
Investigator: Motohiko Oshima
Institution: The University of Tokyo
Funded outputs count: 2
Funder award ID: 18K08348
OpenAlex ID: G775202922