Impact of sarcopenia on immunological function and outcomes in surgical treatment of refractory hepato-biliary-pancreatic diseases aiming for improvement of prognosis
Description: 1)We first clarified that preoperative low skeletal muscle mass, decreased muscle quality, and visceral adiposity were independent risk factors after liver transplantation and resection of hepato-biliary-pancreatic cancer. Implementation of new objective criteria considering preoperative body composition and perioperative rehabilitation as well as nutritional intervention dramatically improved one-year survival rate after liver transplantation (99%).2)Surprisingly, we first demonstrated that high muscle mass and quality of male donor is a protective factor of allograft loss after living donor liver transplantation, independently from donor age.3)Postoperative administration of β-hydroxy-β-methyl-butyrate-enriched formula with rehabilitation significantly increased grip strength at 1 and 2 months and skeletal muscle mass at 2 months and shortened postoperative hospital stay after living donor liver transplantation.
Amount: ¥4,420,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2017-04-01
End date: 2020-03-31
Investigator: Toshimi KAIDO
Institution: St. Luke's International University(2019)Kyoto University(2017-2018)
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Funded outputs count: 9
Funder award ID: 17K10511
OpenAlex ID: G777683266