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Prenatal Exposure to Endocrine Disrupters, DNA Methylation, and Childhood Obesity

Description: RELEVANCE (See instructions): From conception onward, children are continually exposed to chemicals that may adversely impact their health. This proposal examines how one set of endocrine-disrupting chemicals (phthalates and bisphenol A) may change the methylation patterns in the umbilical cord blood of infants and how this predicts subsequent obesity. It develops new methods potentially widely useful in determining how chemicals in the environment affect child health and development.
Funding type: research
Funder scheme: R00
Start date: 2016-04-01
End date: 2020-03-31
Investigator: ALLAN C. JUST
Institution: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
Funded outputs count: 92
Funder award ID: R00ES023450
OpenAlex ID: G2935365437
Newborn mitochondrial DNA copy number is associated with changes to DNA methylation that persist into childhood and are associated with cognitive development
2025 · Allison Kupsco, Jonathan A. Heiss, et al. · Clinical Epigenetics · 3
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Recent ambient temperature and fine particulate matter (PM2.5) exposure is associated with urinary kidney injury biomarkers in children
2023 · Maria D. Politis, Iván Gutiérrez-Avila, et al. · The Science of The Total Environment · 8
Computational deconvolution of fifteen leukocyte subtypes from DNA methylation microarrays trained on flow cytometry data in the Health and Retirement Study
2022 · Jonathan A. Heiss, Kelly M. Bakulski, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 1
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PM2.5 exposure as a risk factor for type 2 diabetes mellitus in the Mexico City metropolitan area
2021 · Olivia L. Chilian-Herrera, Marcela Tamayo-Ortiz, et al. · BMC Public Health · 26
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Can weather help explain 'why now?': The potential role of hourly temperature as a stroke trigger
2021 · Sebastian T. Rowland, Lawrence G. Chillrud, et al. · Environmental Research · 24
Prenatal maternal phthalate exposures and trajectories of childhood adiposity from four to twelve years
2021 · Allison Kupsco, Haotian Wu, et al. · Environmental Research · 28
Critical windows of perinatal particulate matter (PM2.5) exposure and preadolescent kidney function
2021 · Maria José Rosa, Maria D. Politis, et al. · Environmental Research · 19
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A 1-km hourly air-temperature model for 13 northeastern U.S. states using remotely sensed and ground-based measurements
2021 · Daniel Carrión, Kodi Arfer, et al. · Environmental Research · 56
Prenatal urinary concentrations of phthalate metabolites and behavioral problems in Mexican children: The Programming Research in Obesity, Growth Environment and Social Stress (PROGRESS) study
2021 · Elena Colicino, Erik de Water, et al. · Environmental Research · 20
The associations of phthalate biomarkers during pregnancy with later glycemia and lipid profiles
2021 · Haotian Wu, Allan C. Just, et al. · Environment International · 29
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The association between ambient temperature variability and myocardial infarction in a New York-State-based case-crossover study: An examination of different variability metrics
2021 · Sebastian T. Rowland, Robbie M. Parks, et al. · Environmental Research · 22
Exposure to PM2.5 and Obesity Prevalence in the Greater Mexico City Area
2021 · Marcela Tamayo-Ortiz, Martha María Téllez-Rojo, et al. · International Journal of Environmental Research and Public Health · 45
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A spatiotemporal reconstruction of daily ambient temperature using satellite data in the Megalopolis of Central Mexico from 2003 to 2019
2021 · Iván Gutiérrez‐Avila, Kodi B. Arfer, et al. · International Journal of Climatology · 26
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Prenatal PM2.5 exposure and neurodevelopment at 2 years of age in a birth cohort from Mexico city
2021 · Magali Hurtado-Díaz, Horacio Riojas-Rodríguez, et al. · International Journal of Hygiene and Environmental Health · 36
Maternal haemoglobin levels in pregnancy and child DNA methylation: a study in the pregnancy and childhood epigenetics consortium
2020 · Justiina Ronkainen, Anni Heiskala, et al. · Epigenetics · 6
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Association of ambient PM2·5 exposure with maternal bone strength in pregnant women from Mexico City: a longitudinal cohort study
2020 · Haotian Wu, Marianthi-Anna Kioumourtzoglou, et al. · The Lancet Planetary Health · 19
Associations between daily ambient temperature and sedentary time among children 4–6 years old in Mexico City
2020 · Sandy Wong, Alejandra Cantoral, et al. · PLoS ONE · 6
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Prenatal and early life exposure to particulate matter, environmental tobacco smoke and respiratory symptoms in Mexican children
2020 · Nadya Y. Rivera Rivera, Marcela Tamayo-Ortiz, et al. · Environmental Research · 28
Prenatal maternal phthalate exposures and child lipid and adipokine levels at age six: A study from the PROGRESS cohort of Mexico City
2020 · Allison Kupsco, Haotian Wu, et al. · Environmental Research · 28
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Gradient boosting machine learning to improve satellite-derived column water vapor measurement error
2020 · Allan C. Just, Yang Liu, et al. · Atmospheric measurement techniques · 34
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Advancing methodologies for applying machine learning and evaluating spatiotemporal models of fine particulate matter (PM2.5) using satellite data over large regions
2020 · Allan C. Just, Kodi B. Arfer, et al. · Atmospheric Environment · 122
Can ultra short-term changes in ambient temperature trigger myocardial infarction?
2020 · Sebastian T. Rowland, Amelia K. Boehme, et al. · Environment International · 43
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Estimation of Hourly near Surface Air Temperature Across Israel Using an Ensemble Model
2020 · Bin Zhou, Evyatar Erell, et al. · Remote Sensing · 31
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Estimating near‐surface air temperature across Israel using a machine learning based hybrid approach
2020 · Bin Zhou, Evyatar Erell, et al. · International Journal of Climatology · 49
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Association of APOL1 Risk Genotype and Air Pollution for Kidney Disease
2020 · Ishan Paranjpe, Kumardeep Chaudhary, et al. · Clinical Journal of the American Society of Nephrology · 24
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