Molecular epidemiology study of inflammation-associated disease development on the basis of long-term follow-up of atomic-bomb survivors
Description: We observed a significant interaction between certain genotype of CHEK2 gene, which is related to DNA damage response, and radiation exposure dose in the increase risk of proximal colon cancer in atomic-bomb survivors. Among 160,000 SNPs, the number of SNPs with P values less than 10-3 related to breast cancer, liver cancer, and colon cancer risks in atomic-bomb survivors were 10, 8, and 12 SNPs, respectively, but there were no SNPs with P values less than 10-6.As a result of measurement of the membrane type IL-6R (mIL-6R) levels of healthy subjects by IL6R genotypes, the mIL-6R levels of the CD4+ helper T cells of the other genotype group was higher than that of the IL6R-A/A group, and the intracellular O2.- levels were significantly higher.
Amount: ¥16,250,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (B)
Start date: 2015-04-01
End date: 2018-03-31
Investigator: Tomonori HAYASHI
Institution: Radiation Effects Research Foundation
Funded outputs count: 13
Funder award ID: 15H04791
OpenAlex ID: G779071928