Dissecting the enhancer logic governing immune cell fate decisions
Description: Project Narrative T cell dysfunction is a hallmark of cancer and chronic viral infections and targeting dysfunction-associated molecules has had a major clinical impact in cancer immunotherapy. Here, we propose using CRISPR epigenome editing and enhancer knock-in assays to identify exactly which regulatory interactions are necessary and sufficient to induce dysfunction in specific tumor microenvironments. Identifying regulatory mechanisms that govern when, where and how T cell dysfunction develops will be critical to improved outcomes in tumor immunity and chronic viral infection.
Funding type: grant
Funder scheme: DP2
Start date: 2022-09-09
End date: 2027-08-31
Investigator: DEBATTAMA RAI SEN
Institution: MASSACHUSETTS GENERAL HOSPITAL
Funded outputs count: 4
Funder award ID: DP2AI176139
OpenAlex ID: G9000889042