Inflammasomes and the mechanism of thymic demise in aging
Description: PUBLIC HEALTH RELEVANCE: Thymus produces specialized immune cells called T-lymphocytes. With progressive aging, thymus becomes dysfunctional thereby losing its ability to produce T-lymphocytes. The loss of thymic function eventually leads to lower immune surveillance in elderly. This research project is designed to understand the mechanism of loss of thymic function in aging with emphasis on a novel inflammation regulating pathway called the 'inflammasome'. The long-term goal of this project is to develop novel therapeutic strategies to strengthen immune function and enhance the health span of elderly.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R01
Start date: 2013-06-15
End date: 2019-05-31
Investigator: VISHWA DEEP DIXIT
Institution: YALE UNIVERSITY
Funded outputs count: 20
Funder award ID: R01AG043608
OpenAlex ID: G7877982176