The reduction of NLRX1 and its role in pulmonary aging
Description: PROJECT NARRATIVE Although America's aging population has profound implications for society as well as for medicine, the genetic, molecular, and cellular mechanisms involved in “aging lung” are still poorly understood. In this application, we will define the role(s) of NLRX1, a novel mitochondrial molecule, in physiologic pulmonary aging process. In addition, we will test the possibility that interventions that restore the aging-associated reduction of NLRX1 in lungs in vivo may have therapeutic potential to attenuate the structural and functional deterioration of the pulmonary system with aging.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R01
Start date: 2016-08-15
End date: 2021-04-30
Investigator: MIN-JONG KANG
Institution: YALE UNIVERSITY
Funded outputs count: 11
Funder award ID: R01AG053495
OpenAlex ID: G113002213