Establishment of a novel cell fate conversion procedure that may be applicable to regeneration therapy for peripheral nerve injury
Description: Schwann cells play important roles in the regeneration of the peripheral nerve tissue, by secreting neurotrophic factors, producing extracellular matrix, and forming myelin. If transplantation of autologous Schwann cells is possible, such a procedure may provide an ideal regenerative therapy to treat a large nerve defect caused by trauma and by surgical resection of a tumor, as well as diseases associated with functional aberration of Schwann cells.We established a technology to directly convert human fibroblasts into Schwann cells. We have also succeeded in inducing such Schwann cells that may be more suitable for transplantation therapy, and confirmed that they are highly functional.
Amount: ¥3,380,000
Funding type: research
Funder scheme: Grant-in-Aid for Challenging Exploratory Research
Start date: 2016-04-01
End date: 2017-03-31
Investigator: Tsunao Kishida
Institution: Kyoto Prefectural University of Medicine
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Funded outputs count: 0
Funder award ID: 16K15751
OpenAlex ID: G7889802482