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Regulation of B Lymphocyte Defects in Senescent Humans

Description: Aged humans have poor immune responses to infectious agents, vaccines, and cancers which contribute to increased morbidity and mortality. The studies in this application will reveal cellular and molecular deficits within the humoral immune response in aged human subjects and lead to improvement of these for better immune response and vaccine development in the elderly population.

Funder: National Institute on Aging

Funding type: research

Funder scheme: R01

Start date: 2009-09-01

End date: 2015-08-31

Investigator: BONNIE B. BLOMBERG

Institution: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

Funded outputs count: 44

Funder award ID: R01AG032576

OpenAlex ID: G2426505218

Immunometabolic effects of lactate on humoral immunity in healthy individuals of different ages

2024 · Maria Romero, Kate Miller, et al. · Nature Communications · 38

Adipocyte‐derived inflammatory molecules induce senescent B cells through metabolic pathways

2024 · Daniela Frasca, Maria Romero, et al. · Obesity · 8

Phenotypic and functional features of B cells from two different human subcutaneous adipose depots

2023 · Daniela Frasca, Denisse Garcia, et al. · PLoS ONE · 7

Several areas of overlap between obesity and aging indicate obesity as a biomarker of accelerated aging of human B cell function and antibody responses

2022 · Daniela Frasca · Immunity & Ageing · 25

The majority of SARS-CoV-2-specific antibodies in COVID-19 patients with obesity are autoimmune and not neutralizing

2021 · Daniela Frasca, Lisa Reidy, et al. · International Journal of Obesity · 55

Influence of obesity on serum levels of SARS-CoV-2-specific antibodies in COVID-19 patients

2021 · Daniela Frasca, Lisa Reidy, et al. · PLoS ONE · 75

Effects of brief stress management interventions on distress and leukocyte nuclear factor kappa B expression during primary treatment for breast cancer: A randomized trial

2021 · Alain Diaz, Chloe J. Taub, et al. · Psychoneuroendocrinology · 24

Effects of cellular senescence on metabolic pathways in non-immune and immune cells

2020 · Daniela Frasca, Yara Bou Saada, et al. · Mechanisms of Ageing and Development · 34

Aging induces B cell defects and decreased antibody responses to influenza infection and vaccination

2020 · Daniela Frasca, Bonnie B. Blomberg · Immunity & Ageing · 130

Obesity Accelerates Age Defects in Mouse and Human B Cells

2020 · Daniela Frasca, Bonnie B. Blomberg · Frontiers in Immunology · 42

Identification and Characterization of Adipose Tissue-Derived Human Antibodies With “Anti-self” Specificity

2020 · Daniela Frasca, Alain Diaz, et al. · Frontiers in Immunology · 38

The Impact of Obesity and Metabolic Syndrome on Vaccination Success

2020 · Daniela Frasca, Bonnie B. Blomberg · Interdisciplinary topics in gerontology and geriatrics · 47

Immunophenotyping of Human B Lymphocytes in Blood and in Adipose Tissue

2019 · Alain Diaz, Maria Romero, et al. · Methods in molecular biology · 2

B Lymphocytes in Rheumatoid Arthritis and the Effects of Anti–TNF-α Agents on B Lymphocytes: A Review of the Literature

2018 · Ozlem Pala, Alain Diaz, et al. · Clinical Therapeutics · 49

Responders and non-responders to influenza vaccination: A DNA methylation approach on blood cells

2018 · Noémie Gensous, Claudio Franceschi, et al. · Experimental Gerontology · 24

Aging, Obesity, and Inflammatory Age-Related Diseases

2017 · Daniela Frasca, Bonnie B. Blomberg, et al. · Frontiers in Immunology · 371

Adipose Tissue Inflammation Induces B Cell Inflammation and Decreases B Cell Function in Aging

2017 · Daniela Frasca, Bonnie B. Blomberg · Frontiers in Immunology · 66

Metformin improves in vivo and in vitro B cell function in individuals with obesity and Type-2 Diabetes

2017 · Alain Diaz, Maria Romero, et al. · Vaccine · 71

Human peripheral late/exhausted memory B cells express a senescent-associated secretory phenotype and preferentially utilize metabolic signaling pathways

2016 · Daniela Frasca, Alain Diaz, et al. · Experimental Gerontology · 160

Ageing and obesity similarly impair antibody responses

2016 · D Frasca, A Diaz, et al. · Clinical & Experimental Immunology · 44

The generation of memory B cells is maintained, but the antibody response is not, in the elderly after repeated influenza immunizations

2016 · Daniela Frasca, Alain Diaz, et al. · Vaccine · 144

Obesity decreases B cell responses in young and elderly individuals

2016 · Daniela Frasca, Franco Ferracci, et al. · Obesity · 228

B Cell–Specific Biomarkers for Optimal Antibody Responses to Influenza Vaccination and Molecular Pathways That Reduce B Cell Function with Aging

2016 · Daniela Frasca, Bonnie B. Blomberg · Critical Reviews in Immunology · 6

Aging, cytomegalovirus (CMV) and influenza vaccine responses

2015 · Daniela Frasca, Bonnie B. Blomberg · Human Vaccines & Immunotherapeutics · 46

MicroRNAs miR-155 and miR-16 Decrease AID and E47 in B Cells from Elderly Individuals

2015 · Daniela Frasca, Alain Diaz, et al. · The Journal of Immunology · 69