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Chronological Age-Dependent Genomic Instability in Yeast

Funding type: research
Funder scheme: R01
Start date: 2006-07-01
End date: 2011-06-30
Investigator: VALTER D. LONGO
Institution: UNIVERSITY OF SOUTHERN CALIFORNIA
Funded outputs count: 35
Funder award ID: R01AG025135
OpenAlex ID: G7195483794
Fasting-mimicking diet cycles reduce neuroinflammation to attenuate cognitive decline in Alzheimer’s models
2022 · Priya Rangan, Fleur Lobo, et al. · Cell Reports · 69
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Fasting-Mimicking Diet Modulates Microbiota and Promotes Intestinal Regeneration to Reduce Inflammatory Bowel Disease Pathology
2019 · Priya Rangan, Inyoung Choi, et al. · Cell Reports · 312
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Protective effects of short-term dietary restriction in surgical stress and chemotherapy
2017 · Sebastian Brandhorst, Eylul Harputlugil, et al. · Ageing Research Reviews · 64
Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes
2017 · Chia-Wei Cheng, Valentina Villani, et al. · Cell · 331
A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan
2015 · Sebastian Brandhorst, In Young Choi, et al. · Cell Metabolism · 850
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Protein and amino acid restriction, aging and disease: from yeast to humans
2014 · Hamed Mirzaei, Jorge A. Suarez, et al. · Trends in Endocrinology and Metabolism · 248
Prolonged Fasting Reduces IGF-1/PKA to Promote Hematopoietic-Stem-Cell-Based Regeneration and Reverse Immunosuppression
2014 · Chia-Wei Cheng, Gregor B. Adams, et al. · Cell stem cell · 483
Acetyl-CoA Synthetase Is a Conserved Regulator of Autophagy and Life Span
2014 · Hamed Mirzaei, Valter D. Longo · Cell Metabolism · 16
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Tor‐Sch9 deficiency activates catabolism of the ketone body‐like acetic acid to promote trehalose accumulation and longevity
2014 · Jia Hu, Min Wei, et al. · Aging Cell · 54
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Low Protein Intake Is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population
2014 · Morgan E. Levine, Jorge A. Suarez, et al. · Cell Metabolism · 910
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Serine- and Threonine/Valine-Dependent Activation of PDK and Tor Orthologs Converge on Sch9 to Promote Aging
2014 · Mario G. Mirisola, Giusi Taormina, et al. · PLoS Genetics · 86
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Fasting: Molecular Mechanisms and Clinical Applications
2014 · Valter D. Longo, Mark P. Mattson · Cell Metabolism · 1,426
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SIRT 1 but not its increased expression is essential for lifespan extension in caloric‐restricted mice
2013 · Evi M. Mercken, Jia Hu, et al. · Aging Cell · 112
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Somatotropic Signaling: Trade-Offs Between Growth, Reproductive Development, and Longevity
2013 · Andrzej Bartke, Liou Y. Sun, et al. · Physiological Reviews · 288
Short-term calorie and protein restriction provide partial protection from chemotoxicity but do not delay glioma progression
2013 · Sebastian Brandhorst, Min Wei, et al. · Experimental Gerontology · 89
Fasting Enhances the Response of Glioma to Chemo- and Radiotherapy
2012 · Fernando Safdie, Sebastian Brandhorst, et al. · PLoS ONE · 200
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Replicative and Chronological Aging in Saccharomyces cerevisiae
2012 · Valter D. Longo, Gerald S. Shadel, et al. · Cell Metabolism · 598
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Growth Factors, Nutrient Signaling, and Cardiovascular Aging
2012 · Luigi Fontana, Manlio Vinciguerra, et al. · Circulation Research · 76
Fasting Cycles Retard Growth of Tumors and Sensitize a Range of Cancer Cell Types to Chemotherapy
2012 · Changhan Lee, Lizzia Raffaghello, et al. · Science Translational Medicine · 715
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Starvation, detoxification, and multidrug resistance in cancer therapy
2012 · Changhan Lee, Lizzia Raffaghello, et al. · Drug Resistance Updates · 61
Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model
2011 · Min Wei, Federica Madia, et al. · Journal of Visualized Experiments · 13
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Growth Hormone Receptor Deficiency Is Associated with a Major Reduction in Pro-Aging Signaling, Cancer, and Diabetes in Humans
2011 · Jaime Guevara-Aguirre, Priya Balasubramanian, et al. · Science Translational Medicine · 743
Fasting and differential chemotherapy protection in patients
2010 · Lizzia Raffaghello, Fernando Safdie, et al. · Cell Cycle · 113
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Genome-Wide Screen in Saccharomyces cerevisiae Identifies Vacuolar Protein Sorting, Autophagy, Biosynthetic, and tRNA Methylation Genes Involved in Life Span Regulation
2010 · Paola Fabrizio, Shawn Hoon, et al. · PLoS Genetics · 172
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Cell resilience in species life spans: a link to inflammation?
2010 · Caleb E. Finch, Todd E. Morgan, et al. · Aging Cell · 29
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