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Generation of an In Vivo Senescent Cell Atlas: Across the life-course and in pathology

Description: Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Amount: £616,100
Funding type: research
Start date: 2021-08-31
End date: 2026-09-29
Subfield: Physiology
Field: Medicine
Funded outputs count: 9
Funder award ID: BB/T013540/1
OpenAlex ID: G7947630223
Direct methylation sequencing
2023 · Abdulkadir Abakir, Wolf Reik · Nature Chemical Biology · 4
Mitigating age-related somatic mutation burden
2023 · Jan Vijg, Björn Schumacher, et al. · Trends in Molecular Medicine · 27
Comparative Principles of DNA Methylation Reprogramming during Human and Mouse In Vitro Primordial Germ Cell Specification
2022 · Ferdinand von Meyenn, Rebecca V. Berrens, et al. · Developmental Cell · 2
Single-cell multi-omics profiling links dynamic DNA methylation to cell fate decisions during mouse early organogenesis
2022 · Stephen J. Clark, Ricard Argelaguet, et al. · Genome biology · 29
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Spatial profiling of early primate gastrulation in utero
2022 · Sophie Bergmann, Christopher A. Penfold, et al. · Nature · 152
DNMT3A binds ubiquitinated histones to regulate bivalent genes
2022 · Aled J. Parry, Wolf Reik · Nature Genetics · 2
Multi-omic rejuvenation of human cells by maturation phase transient reprogramming
2022 · Diljeet Gill, Aled Parry, et al. · eLife · 185
Multi‐omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming
2022 · Dafni Chondronasiou, Diljeet Gill, et al. · Aging Cell · 134
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8C-like cells capture the human zygotic genome activation program in vitro
2022 · Jasmin Taubenschmid-Stowers, Maria Rostovskaya, et al. · Cell stem cell · 165
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