Role of ERb in female-specific sarcopenia.
Description: Recently, sarcopenia, an age-related progressive loss of muscle mass and strength has been focused. Estrogens are important for comprehensively maintaining muscle function, and an insufficiency affects muscle strength and regeneration in females. In this study, we focused on estrogen receptor (ER)β, which is thought to be involved in skeletal muscle development and regeneration. We generated muscle-specific ERβ‐knockout (mKO) and satellite cell-specific ERβ-knockout (scKO) mice. The mKO mice showed a decrease in both muscle mass and muscle strength. The scKO mice also showed impaired muscle regeneration following acute muscle injury. ERβ plays an important role in skeletal muscle development and regeneration.
Amount: ¥4,160,000
Funding type: fellowship
Funder scheme: Grant-in-Aid for Early-Career Scientists
Start date: 2018-04-01
End date: 2023-03-31
Investigator: Yuriko Kitajima
Institution: Nagasaki University
Subfield: Molecular Biology
Domain: Life Sciences
Funded outputs count: 1
Funder award ID: 18K16804
OpenAlex ID: G7965998670