Investigation of muscle atrophy and sarcopenia in patients with cardiovascular diseases and new rehabilitation methods for its countermeasure
Description: The frequency of sarcopenia was 27.8% for men and 41.8% for females in patients with cardiovascular disease admitted to our Heart Center. The prevalence of sarcopenia was high in patients with heart failure and CKD. Furthermore, we examined blood biomarkers related to muscle atrophy and sarcopenia, and revealed that adiponectin, GDF-15, and acylcarnitine are closely related. In the future, we will extract and quantify microRNAs in exosomes from preserved blood and investigate the further biomarkers. We also examined the effects of new rehabilitation methods, low-intensity electrical stimulation under moderate blood flow restriction known as KAATSU training, and waon therapy using thermal stimulation, as a countermeasure. Particularly, in this study, the fact that basic experiments could prove muscle hypertrophic effect and its underlying molecular mechanisms on skeletal muscles may have provided important information as a basis for future clinical research.
Amount: ¥11,440,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (B)
Start date: 2016-04-01
End date: 2019-03-31
Investigator: Toshiaki Nakajima
Institution: Dokkyo Medical University
Funded outputs count: 14
Funder award ID: 16H03203
OpenAlex ID: G801357285