Analysis of aging and carcinogenesis mechanism using replication incompletion model mice
Description: Inappropriate replication completion may cause genome instability, a characteristic of almost all human cancers. However, the direct relationship between incompletion of replication and cancer remains largely unknown. Here we sought to establish replication completion-related X gene knockout mice to address the hypothesis and confirm the phenotypes. Although we established gene X knockout mice as a mouse model for replication incompletion, we found that gene X is partially essential for viability and the viability depends on mouse strains. It was practically difficult for us to conduct several experiments with these mice. Hence, we changed strategy to make conventional conditional X gene knockout mice. At present, we obtained the floxed X gene mice.
Amount: ¥4,030,000
Funding type: fellowship
Funder scheme: Grant-in-Aid for Young Scientists (B)
Start date: 2015-04-01
End date: 2018-03-31
Investigator: Masaoki KOHZAKI
Institution: University of Occupational and Environmental Health, Japan
Funded outputs count: 5
Funder award ID: 15K21565
OpenAlex ID: G8019584645