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Nose-to-Brain Delivery of Peptide Drugs for Effective Pharmacotherapy of Dementia

Description: The present study aimed to overcome the difficulty in treating severe cognitive dysfunction using insulin by delivering the potential alternatives, GLP-1 receptor agonist (exendin-4) to the brain via the nose-to-brain delivery system by coadministration with penetratin. The distribution of exendin-4 throughout the brain was dramatically increased by intranasal coadministration with the L-penetratin. Furthermore, spatial learning ability after daily administration of exendin-4 with L-penetratin and supplemental insulin for 4 weeks suggested therapeutic efficacy against severe cognitive dysfunction in aged SAMP8. The present study suggests that nose-to-brain delivery of exendin-4 with supplemental insulin, mediated by CPP coadministration, shows promise for the treatment of dementia with progressive cognitive dysfunction.

Funder: Japan Society for the Promotion of Science

Amount: ¥4,160,000

Funding type: fellowship

Funder scheme: Grant-in-Aid for Young Scientists (B)

Start date: 2017-04-01

End date: 2019-03-31

Investigator: Noriyasu Kamei

Institution: Kobe Gakuin University

Topic: Advanced Drug Delivery Systems

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

Funded outputs count: 1

Funder award ID: 17K15440

OpenAlex ID: G8046147114

Effective nose-to-brain delivery of exendin-4 via coadministration with cell-penetrating peptides for improving progressive cognitive dysfunction

2018 · Noriyasu Kamei, Nobuyuki Okada, et al. · Scientific Reports · 55

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