Pathophysiological analyses for early-stage knee osteoarthritis: Pathophysiology and association between meniscus extrusion, osteophyte, and hyaluronan degradation
Description: In this study examining pathophysiology of knee osteoarthritis (OA), medial meniscus extrusion (MME) was closely associated with the medial tibial osteophyte width, which was composed of not only bone-part but also cartilage-part. Medial meniscus (MM) was extruded not only medially (MME) but also anteriorly (AME) and AME was also associated with anterior tibial osteophyte width. The change of MME was also associated with that of medial tibial osteophyte width. The cultures chondrocytes extracted from cartilage part of osteophyte were positive for CD105 and CD166 antibody and their expression was inhibited by IL-6. The expression of HYBID (hyaluronan-binding protein involved in hyaluronan depolymerization；KIAA1199), novel hyaluronan-degrading enzyme, is increased in both cartilage and synovium in knee OA patients. HYBID degradates hyaluronan directly and the expression of HYBID was increased by IL-6 in chondrocyte extracted by knee OA patients.
Amount: ¥4,420,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2018-04-01
End date: 2024-03-31
Investigator: Muneaki Ishijima
Institution: Juntendo University
Funded outputs count: 42
Funder award ID: 18K09082
OpenAlex ID: G8047051637