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Insulin Signaling and Metabolic Regulation in Adipocytes

Funding type: research
Funder scheme: R01
Start date: 1981-09-01
End date: 2012-03-31
Investigator: MICHAEL P CZECH
Institution: UNIV OF MASSACHUSETTS MED SCH WORCESTER
Funded outputs count: 59
Funder award ID: R01DK030898
OpenAlex ID: G1686363297
Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis
2023 · Kyounghee Min, Batuhan Yenilmez, et al. · eLife · 14
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Fatty acid availability controls autophagy and associated cell functions
2023 · Leslie A. Rowland, Michael P. Czech · Autophagy · 9
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Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis
2023 · Kyounghee Min, Batuhan Yenilmez, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 3
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Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program
2023 · Adilson Guilherme, Leslie A. Rowland, et al. · Cell Reports · 34
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The adipocyte supersystem of insulin and cAMP signaling
2022 · Adilson Guilherme, Leslie A. Rowland, et al. · Trends in Cell Biology · 58
CRISPR-enhanced human adipocyte browning as cell therapy for metabolic disease
2021 · Emmanouela Tsagkaraki, Sarah M. Nicoloro, et al. · Nature Communications · 91
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Immunotherapy for Infarcts: In Vivo Postinfarction Macrophage Modulation Using Intramyocardial Microparticle Delivery of Map4k4 Small Interfering RNA
2020 · Jun Luo, Matthew S. Weaver, et al. · BioResearch open access · 2
Single-Cell RNA Profiling Reveals Adipocyte to Macrophage Signaling Sufficient to Enhance Thermogenesis
2020 · Felipe Henriques, Alexander H. Bedard, et al. · Cell Reports · 84
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Control of Adipocyte Thermogenesis and Lipogenesis through β3-Adrenergic and Thyroid Hormone Signal Integration
2020 · Adilson Guilherme, Batuhan Yenilmez, et al. · Cell Reports · 66
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Mechanisms of insulin resistance related to white, beige, and brown adipocytes
2020 · Michael P. Czech · Molecular Metabolism · 245
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Coronary disease is not associated with robust alterations in inflammatory gene expression in human epicardial fat
2019 · Timothy P. Fitzgibbons, Nancy Lee, et al. · JCI Insight · 16
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The Misshapen subfamily of Ste20 kinases regulate proliferation in the aging mammalian intestinal epithelium
2019 · Qi Li, Niraj K. Nirala, et al. · Journal of Cellular Physiology · 9
Molecular pathways linking adipose innervation to insulin action in obesity and diabetes mellitus
2019 · Adilson Guilherme, Felipe Henriques, et al. · Nature Reviews Endocrinology · 171
CRISPR-delivery particles targeting nuclear receptor–interacting protein 1 (Nrip1) in adipose cells to enhance energy expenditure
2018 · Yuefei Shen, Jessica L. Cohen, et al. · Journal of Biological Chemistry · 60
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Neuronal modulation of brown adipose activity through perturbation of white adipocyte lipogenesis
2018 · Adilson Guilherme, David J. Pedersen, et al. · Molecular Metabolism · 39
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Joint analysis of left ventricular expression and circulating plasma levels of Omentin after myocardial ischemia
2017 · Louis A. Saddic, Sarah M. Nicoloro, et al. · Cardiovascular Diabetology · 19
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Insulin action and resistance in obesity and type 2 diabetes
2017 · Michael P Czech · Nature Medicine · 1,253
Map4k4 impairs energy metabolism in endothelial cells and promotes insulin resistance in obesity
2017 · Rachel J. Roth Flach, Marina T. DiStefano, et al. · American Journal of Physiology-Endocrinology and Metabolism · 22
Adipocyte lipid synthesis coupled to neuronal control of thermogenic programming
2017 · Adilson Guilherme, David J. Pedersen, et al. · Molecular Metabolism · 61
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Protein Kinase Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Promotes Obesity-induced Hyperinsulinemia
2016 · Rachel J. Roth Flach, Laura V. Danai, et al. · Journal of Biological Chemistry · 19
Endothelial Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 Is Critical for Lymphatic Vascular Development and Function
2016 · Rachel J. Roth Flach, Chang-An Guo, et al. · Molecular and Cellular Biology · 32
Emerging evidence for beneficial macrophage functions in atherosclerosis and obesity-induced insulin resistance
2016 · Timothy P. Fitzgibbons, Michael P. Czech · Journal of Molecular Medicine · 45
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Peptide- and Amine-Modified Glucan Particles for the Delivery of Therapeutic siRNA
2016 · Jessica L. Cohen, Yuefei Shen, et al. · Molecular Pharmaceutics · 29
Endothelial protein kinase MAP4K4 promotes vascular inflammation and atherosclerosis
2015 · Rachel J. Roth Flach, Athanasia Skoura, et al. · Nature Communications · 114
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NETs and traps delay wound healing in diabetes
2015 · Rachel J. Roth Flach, Michael P. Czech · Trends in Endocrinology and Metabolism · 40
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